Abstract: In order to avoid the damage caused by axial force and electrodynamic force during operation of high-voltage cable, taking 220 kV 2 500 mm² cable as an example, analyzed and calculated the influence of parameters such as half-serpentine pitch and serpentine arc amplitude on axial force and expansion strain of metal sheath during the serpentine laying of cable. The analysis showed that the pitch of serpentine laying arc and the pitch of the half serpentine laying arc play an important role in controlling axial force. At the same time, the electrodynamic force during short circuit was calculated and the arrangement of cable clamps was verified. By setting reasonable serpentine laying parameters, the deformation caused by axial force could be effectively absorbed. This paper could provide reference for parameter design and verification of high-voltage cable serpentine laying.