Abstract: With widespread application of robots in industrial, medical, and service fields, electromagnetic compatibility (EMC) issue of their signal transmission cables has become increasingly prominent. To address the problem, a systematic study on EMC and interference-resistant design of signal transmission cables for robots was conducted in the paper. Electromagnetic interference mechanisms and transmission line theory were analyzed, and comprehensive interference-resistant solutions involving shielding design, grounding strategies, filtering techniques, and wiring optimization were proposed. Simulation and experimental verification demonstrated that employing a double-layer shielding structure could reduce transfer impedance by more than 40%, and optimized wiring strategies could decrease crosstalk by over 30%. Furthermore, the research established an evaluation system for EMC performance of robotic cables, providing theoretical support and a technical basis for the design of highly reliable robotic systems. Finally, combined with research findings, recommendations for industrial applications and future research directions were also presented.