Abstract: Conventional photovoltaic cables are designed based on the requirements for terrestrial use. However, aquatic photovoltaic cables need to be installed in complex and harsh water environments, making general land-based cables unsuitable. To meet the operational requirements of aquatic photovoltaic cables, such as water resistance, termite/ant resistance, tensile resistance, and fungal resistance, this paper takes a DC 1.5 kV photovoltaic cable with a conductor specification of 16 mm² as an example. By designing the conductor layer, buffer layer, and metallic layer, a cable specifically for aquatic photovoltaic power generation was developed. Experimental validation confirms that the developed comprehensive protection cable for aquatic photovoltaic power generation can satisfy the demands of aquatic photovoltaic projects and has broad application prospects.